Beschreibung
ADME Scientist / Bioanalytics & in vitro enzyme assays (m/f/d)
Reference: -en
Start: asap
Duration: 12 MM++
Main tasks:
- Conduct the laboratory work in enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
- Analyzing incubation samples via LC-MS/MS and radio-HPLC, including the method development and/or validation
- Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and in drug development setting reporting to the respective laboratory staff and supervisors
- Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
- Some time may be spent on supporting to develop new enzyme phenotyping methodologies and approaches.
Main qualifications
- PhD or Post Doc in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD)
- Profound experience in similar position
- Experience in bioanalysis & in vitro assays
- Experience in industry
- Excellent knowledge of metabolic enzyme biochemistry (e.g. CYP, UGT), kinetics assessment and the respective experimental designs.
- You have a strong interest in translational approaches leveraging in vitro data and clinical data
- Competence in method development/validation for radio-HPLC (e.g. Thermo) and LC-MS/MS (e.g. Sciex). This includes troubleshooting and data analysis (e.g. Analyst). Please note here experience with “Sciex” is really highly valued
- Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies)
Main advantages:
- You will work in an international environment
About us:
With over 15 years of experience in the pharmaceutical industry, biotechnology and medical engineering, we know the key contacts at companies that are recruiting for challenging jobs with real potential. The current high demand for staff has opened up exciting opportunities for dedicated professionals looking to develop themselves professionally and to further their careers. As recruitment specialists with an international network of contacts, we can offer you decisive advantages – all completely free of charge. Register with us and reap the benefits of job offers that are both interesting and relevant to your skills and experience.
My contact at Hays:
My contact person:
Emina Mustafic
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