Expert ADME - enzymology and DDI (LSW) - BS (m/f/d)

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Data Analysis Automatisierung Biotechnologie Drug Discovery Risikoanalyse


Expert ADME - enzymology and DDI (LSW) - BS (m/f/d)

Reference: -en
Start: asap
Duration: 12 MM

Main tasks:
  • Conduct the laboratory-based assays in in vitro enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
  • Analyzing incubation samples via LC-MS/MS and radio-HPLC, including bioanalytical method development and/or validation.
  • Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and drug development setting reporting to the respective laboratory staff and supervisors.
  • Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
  • Some time may be spent in supporting the development of new enzyme phenotyping methodologies and approaches with the help of automation.

Main qualifications
  • You have a BSc or MSc degree in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD)
  • You gained good knowledge of metabolic enzyme biochemistry (e.g. CYP450, UGT), hands-on/experimental enzyme kinetics assessment and the respective experimental designs
  • Experience in bioanalytical method development/validation for radio-HPLC (e.g. Thermo) and LC-MS/MS (e.g. Sciex). This includes troubleshooting and data analysis (e.g.using Analyst software)
  • You have a strong interest in translational approaches leveraging in vitro data and clinical data

Main advantages:
  • You will get the chance to work on advancing in vitro assay techniques to estimate fractions metabolized by enzymes to support clinical PK prediction and drug-drug interaction (DDI) risk assessment for small molecules portfolios
  • This is an amazing opportunity to integrate an international well known pharmaceutical company

About us:
With over 15 years of experience in the pharmaceutical and chemical industry as well as in biotechnology and medical engineering, we know the key contacts at companies that are recruiting for challenging jobs with real potential. The current high demand for staff has opened up exciting opportunities for dedicated experts who want to develop professionally and to further their careers. As recruitment specialists with an international network of contacts, we can offer you decisive advantages – completely free of charge. Register with us and reap the benefits of interesting job offers that match your skills and experience.

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12 MM
Hays AG
Hays AG
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